hpv25鍩哄洜鍨嬪垎鍨嬫娴嬭瘯鍓傜洅-九游会登录网址

hpv25鍩哄洜鍨嬪垎鍨嬫娴嬭瘯鍓傜洅

2019-3-8


鍖荤枟鍣ㄦ娉ㄥ唽璇佺紪鍙凤細鍥芥娉ㄥ噯20173403364



路e6/e7 dna浣滈澏鐐癸紝閬垮厤婕忔     鐙锛?/span>鐙锛?/strong> 鐙锛?/strong>

路鏈€鍏ㄥ崄鍏涓珮鍗卞瀷锛岀簿鍑嗗垎鍨?/strong>

路鍗曠鍙嶅簲锛屽弻閲嶈川鎺э紝閬垮厤鍋囬槾鎬?/strong>


18绉嶄腑楂樺嵄鍨嬶細16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82

7绉嶄綆鍗卞瀷锛?/span>6, 11,42, 43, 44, 81, 83



            e6/e7 dna浣滈澏鐐癸紝閬垮厤婕忔


hpv瀵艰嚧瀹鐥呭彉鐨勮繃绋嬪浘绀?/span>


鍦–in i 鏈熷強涔嬪墠锛孒pv 涓昏浠ユ父绂荤姸鎬佸瓨鍦ㄤ簬瀹夸富缁嗚優涓紝鍦ㄧ梾鍙樿繘涓€姝ュ彂灞曠殑杩囩▼涓紝hpv 鍩哄洜缁勪細鏁村悎鍒板涓荤粏鑳炲熀鍥犵粍锛岄殢鐫€鐥呭彉绋嬪害鐨勫鍔狅紝hpv 鍩哄洜缁勬渶缁堜互鏁村悎鐘舵€佸瓨鍦ㄣ€?鍦ㄦ暣鍚堝彂鐢熶箣鍚庯紝l1 dna 閫氬父涓㈠け锛岃€孍6/e7 dna 鏃犺鍦ㄧ梾姣掓父绂荤姸鎬佽繕鏄暣鍚堢姸鎬佷細涓€鐩村瓨鍦紝e6/e7 mrna 涔熶細鍦ㄥ熀鍥犵粍鍙戠敓鏁村悎涔嬪悗澶ч噺琛ㄨ揪[1]銆備互l1鍩哄洜浣滄娴嬮澏鐐癸紝浼氬鑷村洜hpv鍩哄洜缁勬暣鍚堣€岄€犳垚鐨勬紡妫€锛屼竴椤圭敱鑽峰叞銆佺編鍥姐€佽嫳鍥姐€佹硶鍥戒互鍙婅タ鐝墮绛夊涓浗瀹剁殑缁勭粐鏈烘瀯鐨勭爺绌跺彂鐜帮紝妫€娴婰1鍖虹殑pcr鏂规硶鍙兘婕忚瘖5-10%鐨勫棰堢檶[2]锛涜€屼互e6/e7 mrna浣滄娴嬮澏鐐癸紝浼氫娇寰楁娴嬬獥鍙e欢鍚庯紝涓嶅埄浜嶩pv鎰熸煋鐨勬棭鏈熺洃鎺с€?/span>



            鏈€鍏ㄥ崄鍏涓珮鍗卞瀷锛岀簿鍑嗗垎鍨?/span>

瀹鐧屾槸鐩墠鍞竴鐥呭洜鏄庣‘鐨勭檶鐥囷紝楂樺嵄鍨婬pv鎸佺画鎰熸煋浼氭渶缁堝鑷村棰堢檶鐨勫彂鐢?sup>[2]銆傚湪涓浗鎰熸煋楂樼骇鍒梾鍙樼殑濂?/span>鎬т汉缇や腑锛屾劅鏌撶巼鎺掑悕鍓嶅崄浣嶇殑hpv鍨嬪埆锛?6銆?2銆?8銆?8銆?3銆?1銆?1銆?3銆?8銆?9[3]銆侶pv妫€娴嬩腑杩涜鍨嬪埆鍖哄垎闈炲父鏈夊繀瑕?sup>[4]銆?/span>


鈥滃叧浜庨珮鍗卞瀷涓庝綆鍗卞瀷鐨勫垝鍒嗭紝鍥介檯涓婅澶氭満鏋勯兘缁欏嚭浜嗗弬鑰冨缓璁紝渚濇嵁who鍥介檯鐧岀棁鐮旂┒鏈烘瀯锛圛arc锛夊強鍏朵粬鍥介檯缁勭粐鐨勭爺绌舵垚鏋滐紝鏈寚瀵煎師鍒欏缓璁皢hpv16銆?8銆?1銆?3銆?5銆?9銆?5銆?1銆?2銆?6銆?8銆?9銆?8绛?3绉嶅熀鍥犲瀷鍒椾负楂樺嵄鍨嬪埆锛?span style="font-family: 寰蒋闆呴粦, "microsoft yahei"; color: rgb(149, 55, 52);">26銆?3銆?6銆?3銆?2绛?绉嶅熀鍥犲瀷鍒椾负涓瓑椋庨櫓鍨嬪埆锛屾湰鎸囧鍘熷垯涓墍杩扮殑妫€娴嬭瘯鍓傚強鍏惰姹傚潎鍙拡瀵圭敤浜庡棰堢檶鐩稿叧棰勬湡鐢ㄩ€旂殑锛堜笂杩?8绉嶏級hpv鍩哄洜鍨嬫牳閰告娴嬶紝濡傜敵鎶ョ殑瀹鐧岀浉鍏矵pv鏍搁吀妫€娴嬩骇鍝佹秹鍙婁笂杩?8绉嶅瀷鍒互澶栫殑鍏朵粬hpv鍩哄洜鍨嬶紝鍒欑敵璇蜂汉闇€鎻愬嚭鏄庣‘鐨勭悊鐢卞拰鎹紝涓斿簲寰楀埌鍥介檯鏈夊叧鏉冨▉鏈烘瀯鐨勬枃鐚敮鎸併€?span style="font-family: 寰蒋闆呴粦, "microsoft yahei"; color: rgb(149, 55, 52);">涓嬫枃涓堪鍙娾€滈珮鍗卞瀷鈥濆潎娉涙寚姝?8绉岺pv鍩哄洜鍨?/strong>銆?/strong>鈥?/span>

鈥斺€斻€婁汉涔冲ご鐦ょ梾姣掞紙hpv锛夋牳閰告娴嬪強鍩哄洜鍒嗗瀷銆佽瘯鍓傛妧鏈鏌ユ寚瀵煎師鍒欍€?/strong>

鍥藉椋熷搧鑽搧鐩戠潱绠$悊鎬诲眬锛圕fda锛?015 骞?1 鏈?6 鏃?鍙戝竷


鈻?鍦ㄤ腑鍥芥劅鏌撻珮绾у埆鐥呭彉鐨勫コ鎬т汉缇や腑锛孒pv鍨嬪埆鐨勬劅鏌撶巼鎺掑簭[3]


鈻?hpv鍒嗗瀷妫€娴嬬殑鎰忎箟[4]


            鍗曠鍙嶅簲锛屽弻閲嶈川鎺?/strong>

鈻?afa/鏂颁竴浠g墖娈靛垎鏋愭妧鏈?/span>[5]

鈻?鎶€鏈?/strong>

鍩轰簬姣涚粏鐢垫吵绯荤粺锛屾柊涓€浠g墖娈靛垎鏋愭妧鏈紙advanced fragment analysis, afa锛夛紝鍙繘琛屽揩閫熴€佺畝鍗曘€侀珮鏁堢殑鏍搁吀鍒嗘瀽銆傚湪hpv妫€娴嬩腑锛?5绉岺pv鍨嬪埆銆佸唴缃弽搴斿唴鍙傚拰浜哄熀鍥犵粍鍐呭弬鍏?7涓澏鐐瑰彲浠ュ悓鏃跺垎鍒鍑恒€傚叾涓紝鍐呯疆鍙嶅簲鍙互鍐呭弬鐩戞帶鏍锋湰妫€娴嬬殑瀹屾暣鎬у強pcr鎶戝埗鐗╃殑瀛樺湪涓庡惁锛涗汉鍩哄洜缁勫唴鍙傚彲浠ラ伩鍏嶇敱浜庢牱鏈笉鍏呰冻鎴栨牱鏈鐞嗛棶棰橀€犳垚鐨勫亣闃存€с€?/span>


鍚屾椂锛屽湪鍙嶅簲浣撶郴涓鍔犻槻姹℃煋鎴愬垎锛岄槻姝㈡娴嬭繃绋嬩腑pcr鎵╁鍚庡埌鎵╁鍓嶇殑姹℃煋銆傚熀浜嶢fa鎶€鏈紝浣垮緱鍙嶅簲浣撶郴閰嶅埗绠€鍗曪紝鎿嶄綔娴佺▼鏇村姞绠€渚裤€?/span>


            浜у搧鐗圭偣

路绮惧噯

鑷寸檶鍩哄洜e6/e7鍋氶澏鐐癸紝閬垮厤鍥燣1鍩哄洜涓㈠け閫犳垚鐨勬紡妫€

18楂樺嵄鍨嬶紝鏈€鍏ㄦ娴嬶紝绮惧噯鍒嗗瀷锛屾棤浜ゅ弶鍙嶅簲

路鍙潬

dutp-ung閰堕槻姹℃煋浣撶郴锛岄伩鍏嶅亣闃虫€?/span>

鐙壒璁捐鐨勫弻閲嶈川鎺э紝閬垮厤鍋囬槾鎬?/span>

路渚挎嵎

鐪熸鍗曠澶氶噸鍙嶅簲浣撶郴锛屾娴嬮澏鐐规洿澶?/span>

鍙嶅簲浣撶郴閰嶅埗绠€鍗曪紝鎿嶄綔娴佺▼绠€渚匡紝杞欢鍒よ缁撴灉鍑嗙‘





            妫€娴嬫祦绋?/strong>

鏍锋湰绫诲瀷锛氬棰堣劚钀界粏鑳炰繚瀛樻恫鏍锋湰銆乀ct鏍锋湰

閰嶅浠櫒锛?/span>



            妫€娴嬬粨鏋滅ず鎰忓浘



鍙傝€冩枃鐚?/span>

[1] woodman c b, collins s, young l s, et al. the natural history of cervical hpv infection: unresolved issues[j]. nature reviews cancer, 2007, 7(1): 11-22.

[2] walboomers j m, jacobs m v, manos m m, et al. human papillomavirus is a necessary cause of invasive cervical cancer worldwide.[j]. the journal of pathology,1999, 189(1): 12-19

[3] ico information centre on hpv and cancer, 2016

[4] 寤栫е骞筹紝璧靛仴 銆婁汉涔冲ご鐦ょ梾姣掑垎鍨嬫娴嬪湪涓村簥宸ヤ綔涓殑搴旂敤銆?涓浗瀹炵敤濡囩涓庝骇绉戞潅蹇? 2010 5锛?6锛?331-333

[5] zhang h, cheng h, wang q, et al. an advanced fragment analysis-based individualized subtype classification of pediatric acute lymphoblastic leukemia.[j].scientific reports, 2015.